How Do Bacteria Handle Mixed Signals? With Surprising Simplicity

Kishony lab explores cell’s response to drug pairs

Mixed signals can be confusing, as the Beatles’ refrain has it. But when the signals come from antibiotic drug combinations, cells react in surprisingly simple ways, HMS researchers have found. Even when drug pairs affect different genes in a single cell in complex ways, the cell as a whole responds in a manner that’s predictable—an insight that could improve drug design.

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