Associate Professor of Physics
Lyman Hall, Room 447
17 Oxford. St
Cambridge, MA 02138
Lab Size: Between 10 to 15
How high-order organization in multi-cellular systems emerge from molecular organization? How function dictates molecular organization? and how does it all evolve?
We look for the fundamental principles that dictate organization in living systems. We employ theory, experiments and computation to address complex question from a quantitative perspective. We work our way from the molecular to the organismic level, looking at bacteria, simple animals, and the interactions among them.
Specifically, we study mechanisms of post transcriptional regulation in bacteria and worms, and characterize how they controls proliferation in the two kingdoms. We then put bacteria and worm together, and ask how information is processed and molecular decisions are made during bacterial infection of the worm.
H. Toledano, C. D’Alterio, E. Levine, and D.L. Jones, IGF-II mRNA binding protein counteracts siRNAs to regulate stem cell niche maintenance in the Drosophila testis, (in submission).
E. Levine, M. Huang, Y.W. Huang, T. Kuhlman, H. Shi, Z. Zhang, and T. Hwa "On Noise and Silence in small RNA regulation", (in submission).
E. Levine and T. Hwa, "Small RNAs establish gene expression thresholds." Current Opinion in Microbiology 11: 574-579 (2008).
E. Levine, P. MacHale and H. Levine, "MicroRNAs may sharpen spatial expression patterns". PLoS Comp. Biol. 3, e233 (2007).
E. Levine, Z. Zhang, T. Kuhlman, and T. Hwa, "Quantitative characteristics of gene regulation by small RNA". PLoS Biol 5, e229 (2007)