Assistant Professor of Biological Chemistry and Molecular Pharmacology
Towards a detailed mechanistic understanding, the FIscher lab has set out to reconstitute complex biochemical processes in recombinant systems and to study the structure function and regulation of ubiquitin ligases. We currently focus on modular systems, such as Cullin RING ligases, which enable more straight forward dissection of function due to the inherent modularity of the multi-component ligase complex. We employ structural biology tools (X-ray crystallography and single particle cryo-EM) combined with biophysical and functional assays. My lab further develops novel approaches to study ubiquitin signaling in a cellular context, which typically is based on quantitative mass spectrometry-based proteomics and sequencing methods, which enables us to understand the direct activity of ubiquitin ligases, the modulation of target function and downstream consequences.