Member of the Faculty
The questions the Singer Lab focuses on center on gaining a systems perspective of the immune system during homeostasis, cancer and autoimmunity. Specifically, we aim to elucidate (1) cell states that vary in function within a given system, along with the changes in abundance and transcription within populations that correlate with a condition of interest (e.g. a specific immunotherapy treatment), (2) the underlying regulatory circuitry that determines a cell’s state within the system, and (3) the mechanisms governing inter-dependencies across cell types and cell states in tissue (e.g. how can a change induced in T cells manifest in a decrease of tumor growth).