Shamil Sunyaev

Harvard New Research Building, Rm 0466C
77 Avenue Louis Pasteur
Boston, MA 02115

Tel: 617-525-4735

Email: ssunyaev@rics.bwh.harvard.edu

Website: http://genetics.bwh.harvard.edu/wiki/sunyaevlab/

Summary

We are a computational genetics and genomics lab. Our main research is on genetic variation, including mechanisms of spontaneous mutagenesis, functional effects of mutations and allelic variants, population genetics and relationship between genotype and phenotype. As part of our research we develop new computational and statistical methods to assist DNA sequencing studies.

Publications

Chun S, Casparino A, Patsopoulos NA, Croteau-Chonka DC, Raby BA, De Jager PL, Sunyaev SR, Cotsapas C. Limited statistical evidence for shared genetic effects of eQTLs and autoimmune disease-associated loci in three major immune cell types.
Nat Genet. 2017 Feb 20. doi: 10.1038/ng.3795. PubMed PMID:28218759.

Sul JH, Cade BE, Cho MH, Qiao D, Silverman EK, Redline S, Sunyaev S. Increasing Generality and Power of Rare-Variant Tests by Utilizing Extended Pedigrees.
Am J Hum Genet. 2016 Oct 6;99(4):846-859. doi: 10.1016/j.ajhg.2016.08.015. PubMed PMID:27666371.

Savova V, Chun S, Sohail M, McCole RB, Witwicki R, Gai L, Lenz TL, Wu CT, Sunyaev SR, Gimelbrant AA. Genes with monoallelic expression contribute disproportionately to genetic diversity in humans.
Nat Genet. 2016 Mar;48(3):231-7. doi: 10.1038/ng.3493. PubMed PMID:26808112.

Kazanov MD, Roberts SA, Polak P, Stamatoyannopoulos J, Klimczak LJ, Gordenin DA, Sunyaev SR. APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions.
Cell Rep. 2015 Nov 10;13(6):1103-9. doi: 10.1016/j.celrep.2015.09.077. Epub 2015 Oct 29. PubMed PMID:26527001.

Akle S, Chun S, Jordan DM, Cassa CA. Mitigating false-positive associations in rare disease gene discovery.
Hum Mutat. 2015 Oct;36(10):998-1003. doi: 10.1002/humu.22847. PubMed PMID:26378430.

Balick DJ, Do R, Cassa CA, Reich D, Sunyaev SR. Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck.
PLoS Genet. 2015 Aug 28;11(8):e1005436. doi: 10.1371/journal.pgen.1005436. eCollection 2015 Aug. PubMed PMID:26317225.

Jordan DM, Frangakis SG, Golzio C, Cassa CA, Kurtzberg J; Task Force for Neonatal Genomics, Davis EE, Sunyaev SR, Katsanis N. Identification of cis-suppression of human disease mutations by comparative genomics.
Nature. 2015 Aug 13;524(7564):225-9. doi: 10.1038/nature14497. Epub 2015 Jun 29. PubMed PMID:26123021.

Francioli LC, Polak PP, Koren A, Menelaou A, Chun S, Renkens I; Genome of the Netherlands Consortium, van Duijn CM, Swertz M, Wijmenga C, van Ommen G, Slagboom PE, Boomsma DI, Ye K, Guryev V, Arndt PF, Kloosterman WP, de Bakker PI, Sunyaev SR. Genome-wide patterns and properties of de novo mutations in humans.
Nat Genet. 47(7):822-6 (2015). PubMed PMID:25985141.

Francioli LC, Polak PP, Koren A, Menelaou A, Chun S, Renkens I; Genome of the Netherlands Consortium, van Duijn CM, Swertz M, Wijmenga C, van Ommen G, Slagboom PE, Boomsma DI, Ye K, Guryev V, Arndt PF, Kloosterman WP, de Bakker PI, Sunyaev SR. Genome-wide patterns and properties of de novo mutations in humans.
Nat Genet. 47(7):822-6 (2015). PubMed PMID:25985141.

Polak P, Karlić R, Koren A, Thurman R, Sandstrom R, Lawrence MS, Reynolds A, Rynes E, Vlahoviček K, Stamatoyannopoulos JA, Sunyaev SR. Cell-of-origin chromatin organization shapes the mutational landscape of cancer.
Nature 518(7539):360-4 (2015). PubMed PMID:25693567.