Professor of Molecular and Cellular Biology

BL3015
The Biological Labs
16 Divinity Ave
Cambridge, MA  02138

Tel:617-496-7201

Email: smango@mcb.harvard.edu

Website: http://projects.iq.harvard.edu/mango_lab

Lab Size: Between 5 and 10

 

Our lab has two broad areas of interest. First, we use C. elegans to investigate how genome organization during embryogenesis. Our goal is to understand how nuclear architecture evolves as cells transition from pluripotency to cell-fate restriction, and the interplay between transcription factors and the dynamic chromatin landscape. These studies have also uncovered influences of the mother and the environment she has experiences and her offspring in a process of cross-generational signaling. Second, we are analyzing the mechanism by which cells build an epithelium. We are particularly interested in i) the timing of polarity initiation and ii) the mechanical forces of embryo morphogenesis and their effects on polarization.