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Ramy Arnaout

Assistant Professor of Pathology

Using the structure and dynamics of biological systems for clinical benefit, especially in immunology, cancer, and infectious disease.

Edoardo Airoldi

Assistant Professor of Statistics

We develop and apply statistical methods for analyzing complex dynamical systems. We are broadly interested in characterizing mechanisms of regulation in bacteria, yeast, and cancer systems, quantitatively. Our focus is on cellular proliferation, metabolism, signaling pathways, and protein-mRNA regulation.

Markus Basan

Assistant Professor of Systems Biology

The complexity and heterogeneity of biological systems are formidable obstacles that must be overcome for achieving a more quantitative and predictive understanding of physiology and phenotypes on the cellular or organism scale. Such a level of understanding has remained largely elusive in biology, despite the extraordinary level of detail to which molecular interactions have been characterized over the past decades, as it often remains unclear how to harness detailed molecular knowledge to achieve this goal.

Michael Baym

Assistant Professor of Biomedical Informatics

The Baym Lab focuses on the evolution of antibiotic resistance, with a goal of developing practical interventions to reduce or reverse resistance. We use a combination of experimental evolution of resistance and computational genomics on clinical samples to learn how resistance evolves and how we might intervene in this process.
 

Michael Brenner

Professor of Applied Mathematics and Applied Physics

Quantitative modeling of complex phenomena in science and engineering.

Martha Bulyk

Professor of Medicine and Pathology

The Bulyk Lab investigates transcriptional regulation. We are particularly interested in transcriptional enhancers and the interactions between sequence-specific transcription factors and their DNA binding sites. For these studies, we develop genomic, proteomic, and computational technologies and approaches and apply them to a wide variety of biological organisms including the yeast S. cerevisiae, the fruit fly D. melanogaster, mouse and human.

George Church

Professor of Genetics

New "omic" measurement technologies (such as FISSEQ) and synthesis and modeling/CAD/analysis tools for gene therapy, whole brain, embryonal and ecological systems.

Stirling Churchman

Assistant Professor of Genetics

We develop high-resolution genomic approaches to understand the molecular mechanisms that control transcription and co-transcriptional processes, such as nascent elongating transcript sequencing (NET-seq), which provides a quantitative measure of RNA polymerase density across the genome with single nucleotide precision.

Philippe Cluzel

Professor of Molecular and Cellular Biology and of Applied Physics

The Cluzel laboratory studies biological signal integration and genetic networks at the single-cell level. We use real-time systems analysis to investigate how single cells respond to information in their environment. Our systems of interest include multi-drug resistance in E. coli and S. aureus, transcriptional dynamics of flagellar genes in bacteria, and degeneracy in the genetic code.

Adam Cohen

Professor of Chemistry and Chemical Biology

The Cohen lab develops physical tools to study molecules and cells. We work on imaging voltage in brains, hearts, embryos, and microorganisms; we study DNA mechanics; we study the effects of weak magnetic fields on chemical reactions; and we study the fundamental physics of light-matter interactions.

Vlad Denic

Professor of Molecular and Cellular Biology

The Denic lab takes advantage of novel methodologies for studying large-scale genetic interactions in budding yeast as well as mass spectrometry-based characterization of natively-isolated protein complexes in order to identify the essential components required for several membrane-associated cellular processes. We then carry out targeted and systematic biochemical reconstitution strategies using the identified components in order to go from parts lists to functional and mechanistic insights.

Angela DePace

Associate Professor of Systems Biology

Our long-term goal is to understand how regulatory DNA dictates transcriptional network behavior and, ultimately, organismal phenotype and evolution. Our approach is mechanistically motivated: we believe that understanding the molecular mechanisms that drive transcription will lead to models of gene regulation that can predict the functional consequences of regulatory sequence changes and guide production of new types of regulatory circuits.

Michael Desai

Professor of Organismic and Evolutionary Biology and of Physics

Mathematical models of evolutionary dynamics, theoretical population genetics, and experimental evolution, all with the goal of understanding how natural selection shapes genetic variation.

Francis J. Doyle III

Professor of Engineering and Applied Sciences

The Doyle lab’s research is focused on two areas: (i) design of algorithms for biomedical devices, and (ii) the application of control & dynamics tools to problems in systems biology, including circadian gene regulation and biomarker identification.

Catherine Dulac

Professor of Molecular and Cellular Biology

Exploring the molecular logic of olfactory signaling underlying the coding of odorant- and pheromone-mediated signals and studying the developmental processes that ensure appropriate neuronal connections between the olfactory sensory neurons and the brain.

Sean Eddy

Professor of Molecular and Cellular Biology and of Applied Mathematics

My research currently focuses on the development of computational methods for RNA, protein, and genome sequence analysis, using probabilistic modeling approaches. Two areas of particular interest are remote protein homology detection, and RNA structure and sequence analysis.  

Walter Fontana

Professor of Systems Biology

The Fontana lab combines experimental and theoretical approaches to address fundamental problems in systems biology as they relate to aging (C.elegans), plasticity in molecular signaling, and the evolvability of phenotype.

Ethan Garner

Assistant Professor of Molecular and Cellular Biology

The Garner lab studies the organization, structure, and dynamics of the prokaryotic cytoplasm. Generally, we are interested in elucidating how small collections of genes are able to impart long range order to cells. Currently, we are using a combination of sub-diffraction imaging, particle tracking, and biochemistry to dissect the mechanistic process of how cells grow and divide. We can observe single molecules of the cell wall synthesis machinery move directionally around the cell circumference, and we are working to understand how these motions create the emergent shape of cells and how they are relate to the control of cell growth.

Yonatan Grad

Assistant Professor of Immunology and Infectious Diseases

We study how pathogens evolve and spread through populations, using genomics, mathematical modeling, and epidemiological tools.

Jesse Gray

Assistant Professor of Genetics

The Gray lab studies how transcriptional networks rewire neuronal circuits.

Jeremy Gunawardena

Associate Professor of Systems Biology

The Gunawardena lab studies information processing in mammalian cells using a combination of experimental, theoretical and computational approaches.

Doeke Hekstra

Assistant Professor of Molecular and Cellular Biology

The Hekstra lab focuses on the study of the mechanics of biomolecules, and more generally the role of physical and evolutionary forces in shaping biological systems.

John Higgins

Assistant Professor of Systems Biology

The Higgins lab combines medical insight, dynamic systems theory, and experiments utilizing microfluidics, video processing, flow cytometry, simulation, and large-scale analysis of medical databases to measure and model the dynamics of human pathophysiologic processes.

Sahand Hormoz

Assistant Professor of Systems Biology

In the Hormoz lab, we combine experiments and theory to understand the complex dynamics of cell state transitions in development and in disease. To do so, we expand and combine emerging experimental techniques.

Curtis Huttenhower

Associate Professor of Computational Biology and Bioinformatics

The Huttenhower lab focuses on the human microbiome, computational metagenomics, sequencing-based microbial community studies, and large-scale biomolecular network analysis.

Marc Kirschner

University Professor of Systems Biology

The Kirschner lab studies spatial organization and temporal control in several different biological contexts, including the cell cycle, the cytoskeleton, and embryonic development. They also study a number of important signaling pathways, notably the Wnt pathway and various post-translational modification systems.

Allon Klein

Assistant Professor of Systems Biology

Dr. Klein is fascinated by the question of how stem cells choose between alternative fates in developing and adult tissues.

Galit Lahav

Professor of Systems Biology

The Lahav lab is using quantitative live-imaging and computational approaches to study how individual human cells “make decisions” in response to external and internal signals. We focus on networks related to cancer development including the DNA damage response and the network regulating the tumor suppressor protein p53.

Erel Levine

Associate Professor of Physics

The Levine lab studies coordinated regulation at the mRNA level and coordination between regulatory modules.

Richard Losick

Professor of Biology

The Losick lab seeks to elucidate the regulatory network that governs the conversion of a growing cell into a spore in the bacterium Bacillus subtilis. This developmental process is orchestrated by the programmed expression of over five hundred genes and involves multiple, novel signal transduction pathways, a bistable switch and dynamic changes in the subcellular localization of regulatory and morphogenetic proteins.

Ying Lu

Assistant Professor of Systems Biology

My lab is trying to understand how the cell achieves accurate control of protein degradation and how its failure may lead to neurodegeneration and aging.

Susan E. Mango

Professor of Molecular and Cellular Biology

The Mango lab focuses on nuclear organization during development, and non-canonical epithelium formation.

Debora Marks

Assistant Professor of Systems Biology

Evolution has deposited rich information in the genomes of all species over time, as a result of mostly hidden functional constraints. The Marks lab will provide mathematical and computational bridge that can exploit this information to address critical challenges in biomedical research such as the consequences of human genetic variation, mutation effect on disease likelihood, drug resistance and drug response.

Sean Megason

Associate Professor of Systems Biology

The Megason lab is interested in how the program contained in the genome is executed during development to turn an egg into an embryo. We use confocal/2-photon imaging of living, transgenic zebrafish embryos to watch biological circuits function in vivo and use these data in cell-based, quantitative modeling.

Franziska Michor

Professor of Computational Biology

We are interested in using the tools of theoretical evolutionary biology, applied mathematics, statistics, and computational biology to address important questions in cancer research.

Timothy Mitchison

Professor of Systems Biology

We work on fundamental questions of how cells are spatially organized applied problems in pharmacology and drug development. We ask how systems comprising microtubules, binding proteins and motors self-organize to promote cell division in frog eggs using microscopy and biochemistry. We work on the pharmacology of microtubule-targeting drugs, and to development new drug that combat cancer and inflammation by modulating innate immunity.

Vamsi Mootha

Professor of Systems Biology and of Medicine

The Mootha lab aims to characterize the structure and dynamic properties of the biological networks underlying mitochondrial function, link variation in these parameters to genetic variation, and exploit the network properties of the organelle to design therapies for human disease.

Andrew Murray

Professor of Molecular Genetics

We use budding yeast in three different ways: 1) to experimentally evolve novel traits, such as multicellularity and circadian clocks, 2) to test our understanding of interesting biological traits by trying to engineer them, and 3) to dissect the regulation of cell biologically interesting processes like polarization, energy homeostasis, and the regulation of the cell cycle.

Daniel Needleman

Associate Professor of Applied Physics

Combining quantitative experiments and theory to understand the architecture and dynamics of self-organizing, subcellular structures, particularly the metaphase spindle.

David Nelson

Professor of Biophysics and of Physics and Applied Physics

The Nelson group's research focuses on collective effects in the physics and chemistry of condensed matter. They have been interested, in particular, in the interplay between fluctuations, geometry and statistical mechanics.

Martin Nowak

Professor of Mathematics and of Biology

Mathematical models of biological systems and evolutionary phenomena, including evolution of cooperation, population structure, evolutionary game theory, evolutionary graph theory, virus infections and somatic evolution of cancer.

Johan Paulsson

Professor of Systems Biology

The Paulsson lab is interested in the sources and consequences of biological noise. They derive mathematical methods to interpret and analyze noise, develop experimental methods to count molecules in single cells, and combine theory and experiment to study the behavior of the simplest natural and engineered networks.

Sharad Ramanathan

Professor of Molecular and Cellular Biology

The research in our lab is directed towards answering two questions: How do cells and organisms process signals from their environment? and How do the underlying molecular pathways evolve?

Aviv Regev

Associate Professor of Biology at MIT and Core Member of the Broad Institute

The Regev lab uses systematic computational and experimental approaches to understand biological circuits on a genome-wide scale. Focusing on carefully selected cell systems, we measure the output of a circuit using genomic tools, generate a computational model that explains our observations, and experimentally perturb key components to test and refine the model.

David Reich

Professor of Genetics

We use statistical genetics and ancient DNA to student human history and biology.

John Rinn

Professor of Stem Cell & Regenerative Biology and of Pathology

The Rinn lab studies the roles of large non-coding RNAs in chromatin formation and their misregulation in disease.

Pardis Sabeti

Associate Professor of Organismic and Evolutionary Biology and of Immunology and Infectious Diseases

The Sabeti's lab aims to study the effect of natural selection on the human genome and on the genomes of other organisms and uncover the traits that have emerged to shape these species, and to understand mechanisms of evolutionary adaptation in humans and pathogens.

Chris Sander

Professor of Cell Biology

The Sander lab focuses on computational & systems biology, statistical physics, and cancer therapeutics.

Alex Schier

Professor of Molecular and Cellular Biology

The Schier lab’s research focuses on two areas: the molecular basis of embryogenesis and the neural regulation of sleep and wakefulness. We mainly use zebrafish as a model system, because genetic and imaging approaches can be combined to study complex behaviors and developmental processes in a vertebrate.

Eugene Shakhnovich

Professor of Chemistry and Chemical Biology

The Shakhnovich Biophysics Lab works on a broad range of topics from Molecular Evolution and Origins of Life to Drug Discovery. Our approach integrates theoretical, computational and experimental work.

William Shih

Associate Professor of Biological Chemistry and Molecular Pharmacology

Explores the principles of self-assembling molecular machine design and evolution, using DNA nanostructures as tools for molecular and structural biology.

Pamela Silver

Professor of Systems Biology

The Silver Lab works at the interface between systems and synthetic biology to design and build biological systems in mammalian and prokaryotic cells.  Current projects include cell-based computing, synthetic chromosomes, novel biological therapeutics and engineering sustainability.

Peter Sorger

Professor of Systems Biology

The Sorger lab applies experimental and computational methods to the analysis of mechanical and regulatory processes controlling eukaryotic cell division. They seek to construct data-driven, systems-wide models of cellular function that contain detailed mechanistic information on the activities of individual proteins.

Michael Springer

Associate Professor of Systems Biology

The Springer lab is interested in how evolution shapes and constrains how organisms respond to their environment. They analyze cellular responses in several related yeast species using a combination of in vivo fluorescence, synthetic and genetic approaches, and numerical and analytical modeling.

Shamil Sunyaev

The primary focus of research in the lab is on genetic variation, including the biology and evolution of mutation, the effect of variation on molecular function and structure, population genetics as a lens on evolution, and the maintenance and allelic architecture of complex traits. We develop computational and statistical methods for sequencing studies. We also have projects in cancer genomics and applied human genetics. The lab encompasses a wide range of skills, backgrounds, and interests spanning these topics.

Ralph Weissleder

Professor of Systems Biology and of Radiology

The Weissleder lab is interested in the development of novel in vivo imaging methods for studying complex human diseases such as cancer and infectious diseases. The lab is also involved in translating these discoveries into the development of new diagnostic devices and drugs.

Xiaoliang Xie

Professor of Chemistry and Chemical Biology

The Xie lab has made advances in room-temperature single-molecule spectroscopy in order to investigate molecular interactions and chemical reactions on a detailed level. Their research has two objectives: (1) to understand conformational and chemical dynamics of biomolecules such as enzymes by single-molecule spectroscopic studies; (2) to image macromolecules and to probe their chemical activities on biological membranes and in living cells with near-field and nonlinear optical microscopy.

Peng Yin

Professor of Systems Biology

The Yin lab’s research lies at the interface of information science, molecular engineering, and biology. They are generally interested in developing programmable molecular systems and technology inspired by biology.

Xiaowei Zhuang

Professor of Chemistry and Chemical Biology and of Physics

The Zhuang research lab works on the forefront of single-molecule biology and bioimaging, developing and applying advanced optical imaging techniques to study the behavior of individual biological molecules and complexes in vitro and in live cells.